DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders
نویسندگان
چکیده
منابع مشابه
DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders
OBJECTIVE The study was planned to investigate whether DHEA supplementation had an impact on endometrial receptivity in women who were poor responders (POR). MATERIAL AND METHODS Twenty-eight POR women who were undergoing hysteroscopy and five fertile control subjects were included. The POR women were equally subdivided into two separate groups as patients who were currently using DHEA and th...
متن کاملDHEA administration in poor responders.
may have been influenced by the presence of M540 bodies. M540 bodies are indeed mysterious structures. They stain positively with merocyanine, a fluorescent membrane probe normally associated with the measurement of membrane potential and disorder, and also generate signals in the TUNEL assay, even though these structures do not stain with DNA sensitive fluorochromes such as YOPRO-1 (Marchiani ...
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Dehydroepiandrosterone (DHEA) is being presented as a miracle-drug for the treatment of women responding poorly to gonadotrophin stimulation, while the debate on its actual effectiveness is still ongoing. We would like to present how insufficient the current evidence of acceptable quality is to warrant a conclusion that DHEA supplementation is an effective treatment for women with diminished ov...
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In fertile women, HOXA-10 and HOXA-11 expression rises during the luteal phase, with the peak occurring during the implantation window, and stays at a high level until the end of the cycle. We evaluated the transcript and protein levels of HOXA-10 and HOXA-11 in the endometria of patients with idiopathic infertility (n = 15) and control patients (n = 10). The amounts of mRNA were determined by ...
متن کاملMechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression.
The establishment of a receptive uterine environment is critical for embryonic survival and implantation. One gene that is expressed in the uterus during the peri-implantation period in mice and is required for female fertility is the homeobox gene Hoxa-10. Here we characterize the peri-implantation defects in Hoxa-10 mutant females and investigate functions of Hoxa-10 in the uterine anlage dur...
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ژورنال
عنوان ژورنال: Journal of the Turkish-German Gynecological Association
سال: 2017
ISSN: 1309-0399,1309-0380
DOI: 10.4274/jtgga.2017.0054